Appomattox, shorthand for the surrender of Robert E. Lee to Ulysses S. Grant in the American Civil War, may refer to:

• Battle of Appomattox Court House, a battle of the American Civil War that was a culmination of the Appomattox Campaign and resulted in the surrender of Robert E. Lee
• Appomattox Court House National Historical Park, a National Historical Park in Virginia at the site of the surrender

Appomattox may also refer to:

• Appomattox County, Virginia, in the United States
  • Appomattox, Virginia, a town and the seat of that county
• Appomattox Court House (disambiguation), several courthouses in Appomattox, Virginia
• Appomattox River, a tributary of the James River in Virginia
• Appomattox Basin, a name for the Tri-Cities, Virginia region
• Appomattox Manor, a manor in City Point, Hopewell, Virginia
• Battle of Appomattox Station, a battle of the American Civil War in Appomattox, Virginia, a day before the Battle of Appomattox Court House
• SS Appomattox, a large American wooden steamship operated mainly on the Great Lakes
• SS Appomattox (1893), a British steamship of the early 20th century
• Appomattox (opera), a 2007 opera in based on the American Civil War, composed by Philip Glass
• Appomattox (statue), a bronze Confederate soldier memorial in Alexandria, Virginia